Impact of kidney function on cardiovascular risk and mortality: A comparison of South Asian and European cohorts
American Journal of Nephrology Nov 11, 2019
Eastwood S, et al. - Researchers focused on ethnic disparities in links between kidney function markers and mortality or cardiovascular disease (CVD), via a baseline cross-sectional analysis and longitudinal follow-up study performed on 1,116 Europeans and 1,104 South Asians of predominantly Indian descent who were included in a UK population-based cohort, with age 52 ± 7 years at baseline (1988–1991). In South Asians vs Europeans, lower eGFRcys [CKD Epidemiology Collaboration (CKD-EPI) eGFR estimating equations based on serum cystatin C] and higher albumin-creatinine ratio (ACR) were detected. South Asians exhibited greater links between ACR and outcomes, compared with Europeans. In Europeans, a modest improvement in the prediction capability was noted when all chronic kidney disease measures were added to a standard CVD risk factor model; in South Asians only ACR contributed to improvement. Overall, a possible greater utility of ACR in CVD risk prediction in South Asians was concluded based on the findings that South Asians of predominantly Indian origin demonstrated strong links between ACR and outcomes and there were null links for eGFRcys and eGFRcreat (eGFR from CKD-EPI-creatinine equations).
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