Makino K, et al. - The effect of infection severity on the clinical outcomes of critical limb ischemia with tissue loss following endovascular treatment was investigated. After analyzing 263 patients (328 limbs) who received endovascular treatment for critical limb ischemia with tissue loss in April 2007–August 2014, researchers noted a negative influence of wound infection severity on clinical outcomes of critical limb ischemia with tissue loss, especially in critical limb ischemia with systemic inflammatory response syndrome. In Rutherford category 5, only clinical outcomes of critical limb ischemia were well-stratified according to infection severity.