Dokras A, et al. - Among 87 overweight/obese women with polycystic ovary syndrome (PCOS) at two academic centres, researchers analyzed the impacts of oral contraceptive pills (OCP), the first-line treatment for PCOS, on high-density lipoprotein cholesterol (HDL-C) function (reverse cholesterol efflux capacity) and lipoprotein particles measured using nuclear magnetic resonance spectroscopy. Findings suggested an association of oral contraceptive pills use with improved HDL-C function and a concomitant atherogenic low-density lipoprotein cholesterol (LDL-C) profile. They observed that combining a Lifestyle program with the use of OCP improved HDL-C function and reduced the adverse effects of OCP on lipoproteins. The investigation shows that OCP is used in overweight/obese women with PCOS in combination with changes in Lifestyle.