Yang J, et al. - Researchers sought to assess the relationship between glycemic status and cognitive performance in men living with HIV (MLWH) vs those without HIV infection via a prospective HIV/AIDS cohort study in four US cities between 1999 and 2016. MLWH vs those without HIV showed abnormalities in glucose metabolism more commonly, which were related to impaired cognitive performance. In the modern antiretroviral therapy era, metabolic status, along with advanced age and previous immunosuppression, may predict cognition with high relevance.