Yeo JW, Ng ZHC, Goh AXC, et al. - In patients with nontraumatic out‐of‐hospital cardiac arrest, improved survival and neurological outcomes were achieved in relation to care at cardiac arrest centers (CACs); this was true irrespective of varying CAC definitions.

• Relevant studies (n=36) from electronic databases were analyzed to examine the effect of CACs on survival in out‐of‐hospital cardiac arrest by varying definitions of CAC and prespecified subgroups.

• Treatment at CACs led to a significantly improved survival with favorable neurological outcome (adjusted odds ratio, aOR: 1.85), even when including high‐volume centers (aOR, 1.50) or including improved‐care centers (aOR, 2.13) as CACs.

• Treatment at CACs also conferred significantly increased survival (aOR, 1.92), even when including high‐volume centers (aOR, 1.74) or when including improved‐care centers (aOR, 1.97) as CACs.

• CACs proved to be more beneficial for patients with shockable rhythms and those without prehospital return of spontaneous circulation.

• Evidence for bypassing hospitals or interhospital transfer is inconclusive.