Rafie MZ, Esmaeilzadeh A, Ghoreishi A, et al. - Researchers conducted the study for analyzing the impact of tPA therapy on interleukin-38 serum level changes and the serum level of IL-38 in the prognosis of ischemic stroke patients in the next three months. Between September 2019 and February 2020, 29 ischemic stroke patients confirmed by a neurologist and based on radiologic and clinical manifestations were enrolled. The findings suggest that tPA could meaningfully increase the IL-38 serum level. A negative correlation has also been discovered between IL-38 serum changes in response to tPA and the modified Rankin Score. The authors conclude that IL-38 serum changes may be a novel early predictor factor for ischemic stroke prognosis because lower changes in IL-38 serum level result in a poorer prognosis.