Mu H, et al. - This case-control investigation was carried out to determine whether IL-10(interleukin-10) -1082 A/G polymorphism impacts the risk of acute kidney injury (AKI). Participants were 320 AKI patients and 408 ICU patients without AKI. The logistic regression analysis adjusted for confounding factors was applied to examine the link between the AKI risk and this polymorphism. An increased risk of AKI was observed in relation to the IL-10 -1082 A/G polymorphism. Following stratified analysis, males, smokers, those aged exceeding 60 years old, and overweight people (BMI ≥ 25) were found to have elevated risk of AKI in relation to this polymorphism. It was found that -1082 A/G polymorphism was remarkably associated with APACHE II score as well as estimated glomerular filtration rate.