Shi Y, et al. - In the present study, the researchers sought to explain the long non-coding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) regulatory network of laryngeal squamous cell carcinoma (LSCC) and clarify its clinical relevance. LSCC transcriptome data were obtained from The Cancer Genome Atlas database and identified the differential expression profile of lncRNAs, miRNAs, and mRNAs by the EdgeR R package. In LSCC tissues, 1961 lncRNAs, 69 miRNAs, and 2224 mRNAs were identified as differentially expressed genes. In LSCC, four lncRNAs from the ceRNA network were found to be abnormally expressed and linked to patient prognosis. They had a significant impact on the progression of LSCC by influencing tumor cell proliferation and metastasis.