• Profile
Close

Identifying Brigham and Women's Hospital stage T2a cutaneous squamous cell carcinomas at risk of poor outcomes

Journal of the American Academy of Dermatology Jan 05, 2022

Gupta N, Weitzman RE, Murad F, et al. - Findings demonstrate an 8% likelihood of developing poor outcomes in BWH (Brigham and Women's Hospital) T2a-high cutaneous squamous cell carcinomas (CSCCs).

  • In this 17-year retrospective multi-institutional cohort study, a predictive model based on tumor characteristics was constructed to unveil risk factors related to poor outcomes (nodal metastasis, distant metastases, and disease-specific deaths) in BWH T2a CSCC.

  • Poor outcomes were best predicted by the presence of 1 major criterion (primary tumor diameter ≥40 mm, invasion depth beyond subcutaneous fat, poor differentiation, or large-caliber perineural invasion) and ≥ 1 minor criterion (invasion depth in subcutaneous fat, moderate differentiation, small-caliber perineural invasion, or lymphovascular invasion).

  • The sensitivity, specificity, positive and negative predictive values yielded by the model were 7.7%, 97.4%, 33.3% and 86.1%, respectively.

  • In these tumors, 5-year cumulative incidence of poor outcomes was estimated to be 8.0% (95% CI, 5.1-13.7) vs 2.8% (95% CI, 1.9-4.1) in other T2a tumors (sub-hazard ratio, 3.0; 95% CI, 1.5-5.8).

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay