Waksman R, Di Mario C, Torguson R, et al. - In this perspective, cohort study, 1,563 individuals with suspected coronary artery disease who underwent cardiac catheterization with possible ad hoc percutaneous coronary intervention from 44 medical centers were enrolled in order to ascertain the association between lipid-rich plaques identified by near-infrared spectroscopy (NIRS)-intravascular ultrasound imaging at unstented sites and following coronary events from new culprit lesions. In people who underwent cardiac catheterization and potential percutaneous coronary intervention, NIRS imaging of non-obstructive territories was concluded as safe and it could help in recognizing individuals and segments at greater risk for following non-culprit major adverse cardiovascular events. Thus, NIRS-intravascular ultrasound imaging contributes to the armamentarium as the first diagnostic tool capable of identifying vulnerable people and plaques in clinical practice.