Luo Y, Lv B, He S, et al. - This research sought to screen potential diagnostic and therapeutic markers for osteosarcoma. Researchers conducted differential expression analysis between osteosarcoma and control in GSE99671, the differentially expressed genes (DEGs) were subjected to co-expression analysis. The biological functions and KEGG signaling pathways of module genes were distinguished by using enrichment analysis. They distinguished a total of 13 co-expression modules from 4,871 DEGs of GSE99671, module 1 had the highest positive correlation with osteosarcoma. The results found that osteosarcoma tumorigenesis and even recurrence status can be effectively distinguished by ATF5, CHCHD8, and LOC286367. As per the findings, this is beneficial for early diagnosis and treatment, improving the clinical treatment of patients with osteosarcoma.