Yu J, Sun S, Mao W, et al. - This research attempted to distinguish enzalutamide resistant-related (EnzR-related) circRNAs and to characterize and validate circRNA-miRNA-mRNA ceRNA regulatory network and corresponding prognostic signature of prostate cancer patients. Researchers collected circRNA expression microarray from the Gene Expression Omnibus database and conducted differential expression analysis to identify EnzR-related circRNAs using the limma package. They constructed circRNA-miRNA-mRNA ceRNA network and PPI network utilizing Cytoscape software and STRING database, respectively. They distinguished 13 EnzR-related circRNAs, and established and confirmed that EnzR-related circRNA-miRNA-mRNA ceRNA network and corresponding prognostic signature could be a beneficial prognostic biomarker and therapeutic target.