Friedman BW, Irizarry E, Chertoff A, et al. - Patients presenting with acute, nontraumatic, nonradicular low back pain (LBP) of no more than 2 weeks’ duration were randomized to receive a 1-week course of ibuprofen plus acetaminophen or ibuprofen plus placebo and were examined for pain and functional outcomes 1 week following emergency department (ED) discharge. The patients with a score > 5 on the Roland Morris Disability Questionnaire, a 24-item validated instrument, indicating more than minimal functional impairment, were recognized as eligible for enrollment immediately prior to discharge from an ED. Prior to discharge, a standardized 10-minute LBP educational session was provided to all patients. Researchers randomized a total of 120 patients who met selection criteria. Outcomes revealed no improved outcomes within 1 week among ED patients with acute, nontraumatic, nonradicular LBP when acetaminophen is added to ibuprofen.