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Hypomagnesuria is associated with nephrolithiasis in patients with asymptomatic primary hyperparathyroidism

Journal of Clinical Endocrinology and Metabolism May 09, 2020

Saponaro F, Marcocci C, Apicella M, et al. - In the present study, the researchers sought to assess the correlation of urinary stone risk factors in individuals with asymptomatic sporadic primary hyperparathyroidism (PHPT) and its clinical relevance. One-hundred fifty-seven consecutive individuals with sporadic asymptomatic PHPT were assessed using serum and 24-hour urinary parameters and kidney ultrasound measurements. According to findings, hypomagnesuria, and urinary calcium/magnesium ratio are each correlated with silent nephrolithiasis and have potential clinical efficacy as risk factors, in addition to hypercalciuria, for kidney stones in asymptomatic PHPT. The findings do not support the other urinary indices that were generally believed to be associated with kidney stones in PHPT.

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