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Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study

PLoS Neglected Tropical Diseases Feb 25, 2019

Behrens I, et al. - Using nationwide Danish register data, researchers examined the associations between hypertensive disorders of pregnancy (HDP; preeclampsia and gestational hypertension) and peripartum cardiomyopathy (PPCM), accounting for other pregnancy-related risk factors for PPCM. Data yielded a cohort of 1,088,063 women with 2,078,822 eligible pregnancies; PPCM developed in 126 women (39 in connection with an HDP-complicated pregnancy). They identified an association of HDPs with substantial increases in PPCM risk that depended on HDP severity, despite the occurrence of 70% of PPCM in women with normotensive pregnancies. Some women already susceptible to cardiac insult displayed higher heart’s capacity to adapt to a normal pregnancy, contributing to PPCM. During pregnancy, HDPs, severe preeclampsia in particular, may represent an additional cardiac stressor.

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