Hayakawa M, et al. – Researchers determined the factors related to hyperfibrinolysis in patients with isolated severe traumatic brain injury (TBI). In TBI and non–TBI patients, an association was evident, between hyperfibrinolysis and tissue injury and trauma severity, respectively. A link between tissue hypoperfusion and hyperfibrinolysis was seen in non–TBI patients, but not in TBI patients. Tissue hypoperfusion may not be a prerequisite for the occurrence of hyperfibrinolysis in patients with isolated TBI.