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Human papillomavirus persistence and association with recurrent cervical intraepithelial neoplasia after cryotherapy vs loop electrosurgical excision procedure among HIV-positive women: A secondary analysis of a randomized clinical trial

JAMA Aug 11, 2021

Chung MH, De Vuyst H, Greene SA, et al. - Among HIV-positive women, loop electrosurgical excision procedure (LEEP) appeared to be more effective in clearing high-risk human papillomavirus (hrHPV) infection when compared with cryotherapy, and persistent detection of hrHPV was linked with recurrent cervical intraepithelial neoplasia.

  • This is a secondary analysis of a randomized clinical trial.

  • Relative to cryotherapy, LEEP was linked with 40% greater likelihood of clearing hrHPV infection.

  • Persistent hrHPV detection was linked with 5 times greater likelihood of developing recurrent cervical intraepithelial neoplasia than no HPV.

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