Martin-Gomez L, et al. - Researchers performed this cohort study with 204 males with newly diagnosed oropharyngeal squamous cell carcinoma to assess the utility of oral gargle samples in determining human papillomavirus genotypes. Using oral gargle samples, they detected most of the clinically relevant human papillomavirus genotypes found in oropharyngeal squamous cell carcinoma. A coinfection with high-risk genotypes was always evident when low-risk human papillomavirus genotypes were detected. They recommend practicing caution while interpreting human papillomavirus detected in oral gargle samples in general cancer risk assessment considering that sensitive assays can concomitantly detect low-risk human papillomavirus genotypes.