Jiménez D, Bikdeli B, Quezada A, et al. - Via performing a multinational population-based cohort study using data from the Registro Informatizado de la Enfermedad TromboEmbólica registry between January 1, 2001, and August 31, 2018, researchers assessed the correlation between experience in the management of acute pulmonary embolism, highlighted by hospital case volume, and mortality. The study sample consisted of 39,257 consecutive patients with a confirmed diagnosis of acute symptomatic pulmonary embolism. A higher burden of comorbidities was noted in individuals with acute symptomatic pulmonary embolism admitted to high-volume hospitals. Between annual hospital volume and pulmonary embolism related mortality, a notable inverse correlation was observed. Compared with admission to hospitals in the lowest quarter, admission to hospitals in the highest quarter was related to a 44% decrease in the adjusted odds of pulmonary embolism related mortality at 30 days. In all sensitivity analyses, results were constant. Among the two quarters, all-cause mortality at 30 days was not significantly reduced. Between the low- and high-volume hospitals, survivors exhibited little variation in the odds of recurrent venous thromboembolism or major bleeding. Thus, admission to high-volume hospitals was associated with important decreases in adjusted pulmonary embolism related mortality at 30 days in patients with acute symptomatic pulmonary embolism. For management approaches, these findings could have implications, according to the investigators.