Alvarez-Sanchez N, et al. - Researchers examined the link among frailty, homocysteine (Hcy) levels and bone turnover in Spanish women between the ages of 65–78 from the Toledo Study for Healthy Aging (TSHA) cohort, who were classified as highly functional (robust subjects) or non-robust (pre-frail or frail subjects) according to Fried's criteria. Frailty status was found to have an integral implication in the link between Hcy and increased bone turnover in older women. In the entire population and in the non-robust group, Hcy was found to be independently related to C-terminal telopeptide of type I collagen (β-CTX) and to N-terminal propeptide of type I procollagen (PINP), but the latter relationship was lost following including the levels of β-CTX, but not the other bone biomarkers, in the multivariate analysis. This indicated that the confounding impacts of β-CTX, at least to a certain extent, might explain the controversial association between Hcy and bone formation.