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HMG-CoA reductase inhibitors and COVID-19 mortality in Stockholm, Sweden: A registry-based cohort study

PLoS Medicine Nov 08, 2021

Bergqvist R, Ahlqvist VH, Lundberg M, et al. - This population-based cohort study demonstrated a modest negative association of statin treatment with coronavirus disease 2019 (COVID-19) mortality. This observation backs the continued employment of statin treatment for medical prophylaxis according to current recommendations also during the COVID-19 pandemic.

  • Data were obtained from Swedish health registers, and a cohort of 963,876 residents of Stockholm, Sweden, was followed from 1 March 2020 until 11 November 2020.

  • Matching of prescription dispensation data to healthcare data and the Swedish Cause of Death Registry was done, and multivariable cause-specific survival analysis was performed.

  • After accounting for a series of preexisting health conditions and other factors, a moderately lower risk of COVID-19 mortality [hazard ratio, 0.88] was observed in relation to statin treatment.

  • The relationship was confirmed by sensitivity analyses and did not differ substantially across risk groups.

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