Zhao Y, et al. - In this investigation, researchers explored the connection between polymorphisms of the HLA-II gene and the effectiveness of house dust mite (HDM)-specific immunotherapy and assessed particular polymorphisms as prospective biomarkers in patients with allergic rhinitis (AR) who would profit most from allergen-specific immunotherapy (AIT). Participants in the study were 51 Han Chinese patients with AR receiving HDM AIT. Based on visual analogue scale and rhinoconjunctivitis quality of life, nasal and eye symptoms were examined. According to findings, allele DRB1*04:06; DRB1*14:05 demonstrated a positive relationship with improvements in nasal blockage, nasal itching, eye itching, and activities. Findings suggested an association of HLA-DRB1 and HLA-DQB1 gene polymorphism with AIT effectiveness in HDM-sensitive Chinese patients with AR, of which DRB1*03:01; DRB1*04:06 and DQB1*03:02:01; DQB1*05:03:01 may be helpful biomarkers of AR patient candidacy for effective AIT.