Nakaguro M, Urano M, Ogawa I, et al. - A total of 28 papillary–cystic tumors of the minor salivary glands were retrieved and histological re-assessment and mutation analyses of various chief oncogenes was performed in order to describe the histological features of these tumors and additional mutational aspects with a special focus on sialadenoma papilliferum (SP) and intraductal papillary mucinous neoplasm (IPMN). SP and SP-intraductal papillary tumor often harbored BRAF V600E mutations which were recognized in both squamous and ductal components. IPMN was characterized by a well-demarcated cystic lesion filled completely with a papillary proliferation of mucinous cells and a high rate of AKT1 E17K mutations. Intraductal papillomas were unilocular cystic lesions with intraluminal papillary growth of bland columnar cells. On the contrary, a multicystic appearance with a papillary configuration was exhibited by both cystadenomas and cystadenocarcinomas. Cystadenocarcinomas invaded the surrounding tissue and were comprised of particularly atypical tumor cells. In conclusion, for the correct diagnosis of minor salivary gland papillary–cystic tumors, the appropriate interpretation of histological findings and specific genetic modifications (eg, BRAF V600E and AKT1 E17K in SP and IPMN) would be beneficial.