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Histopathological and hematological changes in recurrent nasal polyposis

International Forum of Allergy & Rhinology Feb 26, 2019

Brescia G, et al. - A sum of 32 individuals were studied to assess the histological alterations in recurrent chronic rhinosinusitis with nasal polyps (CRSwNP) cases in terms of eosinophilic infiltrate, subepithelial edema, goblet cell hyperplasia, and basement membrane thickness. They observed a significant positive association of all the histopathological parameters with tissue eosinophil and blood eosinophil counts. They also found an independent correlation between basement membrane thickness and tissue eosinophil count and goblet cell hyperplasia at revision surgery. In recurrent disease, again a positive correlation between eosinophil counts in tissue and blood was noticed. A significantly lower mean tissue eosinophil count in recurrent CRSwNP was recorded.
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