Mark Park YM, et al. - Researchers assessed the link between diet-dependent acid load and risk of breast cancer, using multivariable Cox proportional hazards regression as well as data from 43,570 Sister Study participants who completed a validated food frequency questionnaire at enrollment (2003-2009) and satisfied eligibility criteria. They estimated diet-dependent acid load by using the Potential Renal Acid Load (PRAL) score; a greater consumption of protein and phosphorus, and lower consumption of potassium, calcium, and magnesium was indicated by higher scores. According to findings, higher diet-dependent acid load could confer risk, while alkaline diets could protect against the risk for breast cancer. In addition, development of hormone receptor negative breast cancer could be reduced by consuming diets high in fruits and vegetables and low in meat because findings demonstrated a positive correlation of PRAL scores with meat consumption and negative correlation with fruit and vegetable intake.