Li Y, et al. - In this retrospective, single-center study, researchers examined whether polycystic ovary syndrome (PCOS) is associated with chromosomally aberrant miscarriage during treatment with assisted reproductive technology (ART). They performed single nucleotide polymorphism array analysis on samples collected from a total of 328 patients who sent their first trimester miscarried chorionic villus for genetic examination after ART in their center. PCOS was reported in 119 women that comprised cases; controls were comprised of 209 women who had no PCOS. Outcomes suggest a higher risk of miscarrying a chromosomally aberrant embryo/fetus in women with PCOS compared to non-PCOS controls during ART. Spontaneous miscarriage risk in women with PCOS could be effectively mitigated via preimplantation genetic screening.