Caceres P, Savickas G, Murray S, et al. - Whether quantification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in urine sediment from coronavirus disease 2019 (COVID-19) patients correlates with occurrence of acute kidney injury (AKI) and mortality, was inquired herein. Participants were 52 patients with PCR-proven COVID-19, hospitalized between March 15th and June 8th, 2020. In these patients, SARS-CoV-2 viral load in urine sediments (U-viral load) was quantified using qRT-PCR. Identifiable SARS-CoV-2 U-viral load was present in 20 COVID-19 patients (39%), of which 17 (85%) experienced AKI with an average U-viral load 4-times higher vs non-AKI COVID-19 patients. Overall, SARS-CoV-2 kidney tropism was further supported by the data generated in this study. A correlation was evident between a higher SARS-CoV-2 viral load in urine sediments from COVID-19 patients and increased incidence of AKI and mortality. Improved prognosis could be achieved via medical care informed by urinary viral detection among COVID-19 patients with kidney injury.