High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study
PLoS Medicine Nov 08, 2018
Lei J, et al. - Using national registers and comprehensive human papillomavirus (HPV) genotyping, researchers investigated whether there was a link between tumor high-risk human papillomavirus (hrHPV) status and invasive cervical cancer (ICC) prognosis. For this investigation, they performed a nationwide population-based study of ICC cases diagnosed in Sweden from 2002–2011. A significant association was noted between hrHPV positivity and screen-detected tumors, young age, high education level, and early stage at diagnosis. As compared to women with hrHPV-negative tumors, women with hrHPV-positive cervical tumors had considerably better prognosis. Data reported that hrHPV appears to be a biomarker for ICC prognosis, adding to the already established prognostic factors age, clinical stage, and histological type.
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