High programmatic isoniazid preventive therapy (IPT) use in pregnancy among HIV-infected women
Journal of Acquired Immune Deficiency Syndromes Aug 27, 2019
LaCourse SM, Wagner AD, Cranmer LM, et al. - Given the World Health Organization recommendation of isoniazid preventive therapy (IPT) for people living with HIV (PLHIV) to prevent tuberculosis (TB), including pregnant women, researchers sought to assess data regarding programmatic IPT use in pregnant PLHIV. In an infant TB prevention trial in Kenya, 300 HIV-infected women were enrolled at 6 weeks postpartum between August 15, 2016 to June 6, 2018. Previous IPT was reported in 224 (74.7%) of these women; 155/224 (69.2%) had any pregnancy IPT use. Observations thereby suggest a high programmatic IPT use in pregnant PLHIV, with periconception and early pregnancy initiation seen often. They noted an association of pregnancy/early postpartum IPT initiation with a new pregnancy HIV diagnosis. Among women with sufficient time to complete before trial enrollment, 6-month IPT completion rates were high [147/160 (91.9%)]; they were and comparable among preconception or during pregnancy initiators.
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