Ban X, et al. - In this investigation, researchers ascertained if the expression of minichromosome maintenance protein 7 (MCM7) was correlated with the risk of pancreatic neuroendocrine neoplasms (PanNENs) progression. In terms of stage, grade, Ki-67 index, MCM7 index and other pathological features, they evaluated the clinical behavior of 156 PanNENs. The data presented in this work showed a significant association of high MCM7 index with larger tumor size, nonfunctioning tumor, increased grade and later TNM stage. In stages I-V, I-III, and I-II, MCM7 labeling index >5% was related to an increased risk of progression. Overall, the investigators confirmed that MCM7 is a valuable marker for the assessment of PanNEN progression, particularly in patients with early-stage disease and without distant metastasis.