Djohan YF, et al. – In this study involving 32 young male Wistar rats, researchers examined how high intakes of palm oils (PO; both crude and refined) and virgin olive oils (OO) metabolically impact surrogate parameters of glucose tolerance, hepatic lipid metabolism, and liver integrity. The investigators divided the Wistar rates into four equal groups and fed them either a control diet (11% energy from fat) or three high-fat diets rich in POs or in OO (56% energy from fat) for 12 weeks, and compared outcomes. They noted a compromised glucose tolerance rats with high dietary intake of PO, whereas high dietary intake of OO compromised hepatic lipid composition and liver integrity. Given that humans may experience different effects compared with rodent model and that the average normal OO amounts ingested in the study population were lower than those corresponding to a high-fat diet, the authors noted that the adverse hepatic effects of OO in this study may not be transposed to human.