Ding XS, et al. - Given that admission hyperglycemia, a usual predictor of poor clinical outcomes for non-diabetes mellitus, is often seen in patients with acute myocardial infarction (AMI), researchers performed this retrospective study to define the suitable cut-point to recognize high-risk individuals in these patients. Three groups of 1,698 non-diabetes AMI patients were defined based on admission glucose levels (euglycemia group≤140 mg/dL, moderate hyperglycemia group 141–179 mg/dL, severe hyperglycemia group≥180 mg/dL). Age, logarithm of the N-terminal pro-brain natriuretic peptide, insufficient myocardial reperfusion, percutaneous coronary intervention and admission glucose were identified as independent predictors of the in-hospital death rate in non-diabetic patients with AMI. With the rise in admission glucose levels, a remarkable increase in all-cause in-hospital mortality risk was evident in non-diabetic patients with AMI, this was particularly seen in patients with admission glucose levels ≥180 mg/dL. For non-diabetic AMI patients, severe admission hyperglycemia could be considered as a prospective high-risk marker.