Arif AA, Chahal D, Ladua GK, et al. - Because the incidence of early-onset colorectal cancer (EoCRC) in people < 50 years is increasing, researchers sought to distinguish the characteristics and outcomes of EoCRC in patients with sporadic disease or preexisting conditions. In a population-based cohort from the Canadian province of British Columbia, 2,135 patients with EoCRC were evaluated. Patients with hereditary syndromes (n = 146) or IBD (n = 87) were identified and compared with patients with sporadic EoCRC (n = 1,902). The proportions of patients with preexisting conditions were highest in the 18-29 age group. Survival was lower in IBD patients and higher in hereditary EoCRC compared with sporadic. EoCRC is heterogeneous and patients with preexisting conditions have different characteristics and outcomes than those with sporadic disease.