Ngongondo MN, et al. - Researchers performed a multicenter study in resource-limited settings with high burden of tuberculosis to determine the risk factors for hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) in severely immunosuppressed people with HIV. They noted a high incidence of hepatotoxicity during IPT and ART. Closer monitoring for hepatotoxicity was thus recommended in severely immunosuppressed individuals with raised pretreatment aspartate aminotransferase (AST)/alanine aminotransferase (ALT) or hepatitis B surface antigen seropositivity.