Bergløv A, et al. - Via performing this systematic review, maternal, fetal and neonatal case-fatality rates as well as the prevalence of adverse outcomes in relation to hepatitis E virus infection during pregnancy were determined. Searching Pubmed, Embase, Cochrane and CINAHL, researchers identified 23 eligible studies, all observational, with a total of 1338 cases. They noted the median maternal, fetal and neonatal case-fatality rates of 26% [interquartile range (IQR) 17%-41%], 33% (IQR 19%-37%) and 8% (IQR 3%-20%), respectively. As per findings, pregnant women infected with hepatitis E virus have a high case-fatality rate. In addition, these women and their children exhibit a high rate of adverse outcomes. The application of findings obtained in this study is restricted to hospital settings and symptomatic pregnant women from endemic countries.