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Hepatitis D-associated hospitalizations in the United States: 2010–2018

Journal of Viral Hepatitis Feb 05, 2022

Researchers herein analyzed hospitalization data from the 2010–2018 National Inpatient Sample from the Healthcare Cost and Utilization Project with the aim to ascertain the incidence of hepatitis D-associated hospitalizations in the United States. Further, they reported the clinical, demographic and geographic characteristics of those hospitalizations.

  • A total of 3,825 hepatitis D-associated hospitalizations were identified.

  • For hepatitis D, a hospitalization rate between 6.9 and 20.7 per 10,000,000 was noted, which changed insignificantly over time.

  • A greater proportion of males, Hispanics, hospitalizations in the Northeast region were observed in the hepatitis D cohort when compared to HBV only.

  • There were significantly greater frequencies of liver failure, non-alcoholic cirrhosis, portal hypertension, ascites and thrombocytopenia in correlation with the hepatitis D-associated hospitalizations.

  • While hepatitis D linked with mortality similar to that of HBV only, there were increased odds of mortality within the hepatitis D cohort in correlation with age > 65 years and having a diagnosis of alcoholic cirrhosis.

  • Although relatively uncommon, the hepatitis D-associated hospitalizations were associated with severe complications.

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