Del Rosario A, Eldredge JD, Doorley S, et al. - Researchers sought to outline the available evidence on hepatitis C virus (HCV) care cascade outcomes in people experiencing homelessness in the US in the era of direct-acting antiviral agents (DAAs). Linkage to care (evaluation by a provider that can treat HCV) and sustained virologic response (SVR) or cure were primary and secondary outcomes. Other cascade data, such as treatment initiation, which comes before SVR, were included in exploratory outcomes. The proportion of chronically infected cohorts with unstable housing who were linked to care ranged from 29.3% to 88.7%. In comparison to the general US population prior to DAAs, such findings show that people experiencing homelessness have a higher rate of linkage to care in non-specialist community-based settings. However, DAA initiation was discovered to be a rate-limiting step along the care cascade, resulting in commensurate low rates of cure.