Yu M, Dai X, Yu L, et al. - Researchers aimed at ascertaining if statin treatment can improve hemodynamic status of coronary atherosclerotic plaque. They prospectively enrolled 152 patients (mean age: 67.1±9.7 years; 100 men; mean follow‐up duration: 13.9±2.5 months) with intermediate pretest probability of coronary artery disease and performed coronary computed tomography angiography (CCTA) at baseline as well as at follow‐up. The lesion‐specific change of △computed tomography‐derived fractional flow reserve (△CT‐FFR, defined as the change of CT‐FFR value across each lesion) after rosuvastatin treatment was assessed as the primary end point. The secondary end point comprised comparison of the change of other plaque characteristics according to serial CCTA findings. Per outcomes, patients with mild to intermediate coronary stenosis showed reduction in lesion‐specific △CT‐FFR at mid‐term follow‐up in correlation with undergoing rosuvastatin treatment. They identified this hemodynamic improvement mainly for non‐calcified lesions.