Ticala M, Rusu CC, Moldovan D, et al. - In hemodialysis (HD) patients, baseline, systemic soluble receptor for advanced glycation end products (sRAGE) was identified to be related to the occurrence of thrombosis of arteriovenous fistula (AVF), and this marker significantly influences AVF survival.

• This study involved 88 prevalent HD patients with functional AVF, to assess the link of serum sRAGE with AVF failure due to thrombosis in such cases.

• Multivariate Cox regression analysis showed sRAGE as a significant predictor of vascular access thrombosis (hazard ratio = 1.15).

• A significantly lower AVF patency time in relation to sRAGE >16.78 ng/mL vs sRAGE <16.78 ng/mL was revealed in Kaplan-Meier analysis.

• In the subgroup of patients with stenosis at baseline, the following factors were linked with thrombosis: sRAGE, serum albumin, obesity, and ischemic heart disease.