Patel NH, Osborne M, Teague H, et al. - In psoriasis, heightened splenic as well as bone marrow (BM) uptake of ¹⁸ F-fluorodeoxyglucose ( ¹⁸ F-FDG) was identified to be related to proatherogenic lipids, immune cells, inflammatory markers and coronary artery disease. These results indicate that immune cell proliferation in the spleen and BM is related to subclinical atherosclerosis in psoriasis.

• According to preclinical studies in psoriasis models, there exists a link between chronic inflammation and immune cell proliferation in the spleen and BM.

• This study involved 240 participants (210 with psoriasis and 30 healthy) to determine if splenic and BM ¹⁸ F-FDG uptake is heightened in psoriasis and whether higher uptake relates to systemic inflammation and subclinical atherosclerotic disease measures.

• Psoriasis patients showed elevated splenic and BM ¹⁸ F-FDG uptake (vs healthy volunteers).

• Fully adjusted models revealed association of higher splenic ¹⁸ F-FDG uptake with higher total coronary burden, non-calcified burden, and lipid rich necrotic core.

• Similar links were noted for BM ¹⁸ F-FDG uptake in adjusted models.