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Heart rate variability is an independent predictor of lymph node metastasis in patients with cervical cancer

Cancer Management and Research Nov 26, 2021

Wang J, Liu J, Gao L, et al. - Researchers examined if assessment of preoperative heart rate variability (HRV) could aid in predicting lymph node metastasis (LNM) in patients with cervical cancer (CC).

  • A total of 77 patients were included, 18 with LNM and 59 with no LNM.

  • HRV time domain, frequency domain and Poincaré plot parameters (ie, SDNN, RMSSD, LF, HF, LF/HF, SD1, SD2 and SD2/SD1) were determined via analyzing a 5-minute resting electrocardiogram (ECG) obtained before surgery.

  • Findings revealed significantly lower SDNN, LF, and SD2 in the LNM group vs the non-LNM group.

  • Overall, HRV is identified to be linked with CC LNM, and could have a potential value as noninvasive biomarker for the prediction of LNM in CC patients.

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