Alvi RM, et al. - Using a cohort comprising 2,308 individuals admitted with decompensated heart failure (HF), researchers compared HF outcomes among persons living with HIV (PLHIV) with HF vs individuals without HIV with HF. Baseline characteristics, 30-day HF readmission, and cardiovascular (CV) and all-cause mortality were compared. Among the overall study population, 374 (16%) were PLHIV with HF, of these, 92% were on antiretroviral therapy and 63% had a viral load (VL) <200 copies/mL. Regarding age, sex, race/ethnicity, and CV risk factors, groups were similar. Increased 30-day HF readmission (49% vs 32%) and CV (26% vs 13.5%) and all-cause mortality rates (38% vs 22%) were observed in PLHIV during the follow-up. Predictors of 30-day HF readmission among PLHIV included cocaine use, HIV-specific parameters (CD4, VL), and coronary artery disease. An increased 30-day HF readmission rate, as well as increased CV and all-cause mortality, was seen in PLHIV with a low CD4 count or detectable VL. HF outcomes in PLHIV with a higher CD4 count and undetectable VL were similar to uninfected controls.