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Headache as an acute and post COVID-19 symptom in COVID-19 survivors: A meta‐analysis of the current literature

European Journal of Neurology Aug 04, 2021

Fernández-de-las-Peñas C, Navarro-Santana M, Gómez-Mayordomo V, et al. - According to this meta-analysis, the prevalence of post-COVID headache ranged from 8 to 15% during the first six months after SARS-CoV-2 infection.

  • There were 28 peer-reviewed studies and 7 preprints among the 9,573 studies found.

  • The sample consisted of 28,438 COVID-19 survivors (12,307 females; mean age: 46.6, SD: 17.45 years).

  • The overall prevalence of post-COVID headache was 47.1% at the time of onset or hospital admission, 10.2% at 30 days, 16.5% at 60 days, 10.6% at 90 days, and 8.4% at ≥ 180 days after onset/hospital discharge.

  • Headache was more common in non-hospitalized patients than in hospitalized patients during the acute phase.

  • Time trend analysis revealed a reduction in prevalence from the onset of the acute symptom to all post-COVID follow-up periods, which was sustained after.

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