McMahon BJ, Nolen LD, Snowball M, et al. - In Alaska Native (AN) persons with chronic HBV (CHB), where five HBV genotypes are found (A2, B6, C2, D, and F1), a strong correlation appeared between HBV genotype and HCC occurrence. Hence risk factor stratification should include HBV genotype.

• Among 1,185 AN persons, the HBV genotype distribution was 49% D, 18% F, 13% A, 6% C, 3% B, 0.1% H, and 12% undetermined.

• There was an occurrence of 63 cases of HCC during the median follow-up period of 35.1 years.

• For genotypes F, C, and A, higher HCC risk was recorded when compared with genotypes B and D.

• Genotype F had the highest incidence among men < 40 years of age and women < 50 years of age (4.79/1,000 person-years).