van Haalen FM, van Dijk EHC, Savas M, et al. - In a cohort of patients with chronic central serous chorioretinopathy (cCSC), researchers examined hair cortisol concentrations (HCC), as a reflection of chronic endogenous steroid exposure. HCC has been determined in 48 individuals with cCSC and 230 population-based controls (Lifelines cohort study), not using exogenous corticosteroids. According to this cross-sectional study, increased HCC (defined as > 10.49 pg/mg) were present in 2 patients with cCSC and 13 controls. Compared with population-based controls, HCC in patients with cCSC were not elevated, there was no connection between HCC and cCSC severity. This result contradicts the previous suggestion that cCSC is linked to increased hypothalamic-pituitary-adrenal axis activity. In particular, HCC does not appear helpful in monitoring cCSC disease activity.