López-Siguero JP, Martínez-Aedo MJ, Bosch-Muñoz J, et al. - In children born small for gestational age (SGA), long-term growth hormone (GH) treatment did not promote insulin resistance (IR) and was well-tolerated, safe and effective, as observed during a period of 10 years.

• In this multicenter observational study, 389 SGA-children who underwent GH treatment in Spain (stratified by Tanner-stage and age at GH onset [two groups: ≤6 years old or >6 years old]) were included.

• At GH therapy initiation, the mean age (standard deviation) of the children was 7.2 (2.8) years old.

• Significant increase in HOMA-IR (homeostatic model assessment-IR) values was observed during the first year of GH-treatment, and HOMA-IR values continued to be stable and were within normal ranges in all cases.

• A significant increase in height (standard deviation score) (basal: −3.0; tenth year: −1.13) was noted, and the maximum height velocity (standard deviation score) occurred during the first year (2.75 ± 2.39).