Hecking M, et al. - In this retrospective cohort study, researchers intended to gain clarity regrding the link between fluid overload and interdialytic weight gain (IDWG), and the prognostic importance of two clinically distinct, bioimpedance spectroscopy (BIS)-derived measures, pre-dialysis and post-dialysis fluid overload (FOpre and FOpost) vs IDWG in a large international hemodialysis population. For mortality, FOpre and FOpost were noted to be consistently positive risk factors. Low IDWG was found to be related to short-term mortality. This was possibly indicative of an influence of protein-energy wasting. Not IDWG but volume status was reflected by FOpost, suggesting that this fluid marker is clinically most intuitive and may be best suited to guide volume management in haemodialysis patients.