Brewer MJ, Doucette JT, Bar-Mashiah A, et al. - This study’s findings demonstrate that glycemic elevations and weight loss predate pancreatic ductal adenocarcinoma (PDAC) diagnosis. It has been considered that these metabolic changes may suggest an underlying PDAC.

• Researchers recruited a total of 4,626 patients: 1,542 cases and 3,084 controls; median age was 69.3 years and 2,487 (53.8%) were male; 751 (48.7%) cases were non-Hispanic white.

• HbA1c was higher in PDAC cases compared to controls in the 3 years prior to diagnosis; a similar trend was seen for glucose values.

• For all study periods, BMI was greater for PDAC cases, except 0-6 months prior to cancer diagnosis when BMI was lower (p <0.01 for all).

• It was shown that change in BMI (ΔBMI) of cases at 1 year and 6 months before diagnosis was -0.59 and -1.21 when compared to -0.08 and 0.03 for controls (p <0.01 for both).

• The data indicated that HbA1c slope (aOR 1.33, 95% CI 1.01-1.76) and BMI slope (aOR 0.75, 95% CI 0.65-0.87) were predictors of PDAC in this multivariable logistic regression.