Deruelle P, et al. - Researchers performed a comparison of oral glyburide and subcutaneous insulin for prevention of perinatal complications in women with gestational diabetes mellitus (GDM). Statistically, results did not demonstrate non-inferiority of the glyburide since the non-inferiority limit was included in the confidence interval. However, glyburide as an option in clinical treatment strategy of GDM should be considered because of stress free use of oral glyburide, small difference in frequency of the composite criterion, improved maternal glycemic control with low number of hypoglycemia with better maternal satisfaction compared to insulin.