Chau LTC, Hu Z, Ko KSY, et al. - This study was carried out to assess the values of global sagittal alignment parameters, including the spine, pelvis, and lower limbs, in patients with and without vertebral compression fractures (VCFs), as well as to evaluate the effect of VCFs on various quality of life parameters. Between May 2015 and June 2018, researchers performed a cross-sectional study including a total of 142 patients with VCFs aged over 60 years old and 108 age-matched asymptomatic controls. They assessed whole body sagittal alignment including thoracic kyphosis, lumbar lordosis, pelvic tilt, pelvic incidence, sagittal vertical axis, T1-pelvic angle, knee-flex angle, and ankle-flex angle. This study’s findings demonstrate that the abnormal lower limb alignment showed in patients with VCF. Individuals with VCF exhibited an overall worse global sagittal alignment and reduced quality of life. According to the results, poorer global sagittal alignment of VCF patients also suggests a worse quality of life and more severe VCF.